The p75NTR extracellular domain
نویسندگان
چکیده
منابع مشابه
The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA.
The TrkA receptor is activated primarily by nerve growth factor (NGF), but it can also be activated by high concentrations of neurotrophin 3 (NT-3). The pan-neurotrophin receptor p75(NTR) strongly inhibits activation of TrkA by NT-3 but not by NGF. To examine the role of p75(NTR) in regulating the specificity of TrkA signaling, we expressed both receptors in Xenopus oocytes. Application of NGF ...
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ژورنال
عنوان ژورنال: Prion
سال: 2011
ISSN: 1933-6896,1933-690X
DOI: 10.4161/pri.5.3.16896